Air quality monitoring and assessment are essential issues for sustainable environmental protection. The monitoring process is composed of data collection, evaluation, and decision-making. Several important pollutants, such as SO2 , CO, PM10, O3 , NOx, H2S, location, and many others, have important effects on air quality. Air quality should be recorded and measured based on the total effect of pollutants that are collectively prescribed by a numerical value. In Canada, the Air Quality Health Index (AQHI) is used which is one numerical value based on the total effect of some concentrations. Therefore, evolution is required to consider the complex, ill-defined air pollutants, hence several naive and noble approaches are used to study AQHI. In this study, three approaches such as hybrid data-driven ANN, nonlinear autoregressive with external (exogenous) input (NARX) with a neural network, and adaptive neuro-fuzzy inference (ANFIS) approaches are used for estimating the air quality in an urban area (Jeddah city—industrial zone) for public health concerns. Over three years, 1771 data were collected for pollutants from 1 June 2016 until 30 September 2019. In this study, the Levenberg-Marquardt (LM) approach was employed as an optimization method for ANNs to solve the nonlinear least-squares problems. The NARX employed has a two-layer feed-forward ANN. On the other hand, the back-propagation multi-layer perceptron (BPMLP) algorithm was used with the steepest descent approach to reduce the root mean square error (RMSE). The RMSEs were 4.42, 0.0578, and 5.64 for ANN, NARX, and ANFIS, respectively. Essentially, all RMSEs are very small. The outcomes of approaches were evaluated by fuzzy quality charts and compared statistically with the US-EPA air quality standards. Due to the effectiveness and robustness of artificial intelligent techniques, the public’s early warning will be possible for avoiding the harmful effects of pollution inside the urban areas, which may reduce respiratory and cardiovascular mortalities. Consequently, the stability of air quality models was correlated with the absolute air quality index. The findings showed notable performance of NARX with a neural network, ANN, and ANFIS-based AQHI model for high dimensional data assessment.