Climate change has challenged biodiversity conservation practitioners and planners. In this paper, we provide scalable guidance on integrating climate change into conservation planning and adaptive management that results in the most appropriate conservation strategies. This integrated “Climate-Smart Conservation Practice” focuses on analyzing the potential impact of climate change on species, ecosystems, and ecosystem services, combined with “conventional” (non-climate) threats, and incorporating this knowledge into projects. The guidance is based on the already widely-used “Open Standards for the Practice of Conservation”, an application of systems thinking and adaptive management, which has been successfully applied to thousands of conservation projects. Our framework emphasizes a methodical analysis of climate change impacts for projects to support more productive goals and strategy development. We provide two case studies showing the applicability and flexibility of this framework. An initial key element is developing “situation models” that document both current and future threats affecting biodiversity while showing the interactions between climate and conventional threats. Guidance is also provided on how to design integrated, climate-smart goals and strategies, and detailed theories of change for selected strategies. The information and suggestions presented are intended to break down the steps to make the process more approachable, provide guidance to teams using climate change information within a systematic conservation planning process, and demonstrate how climate scientists can provide appropriate information to conservation planners.