Climate change presents potential risks to forests and challenges for forest managers. Adaptation to climate change involves monitoring and anticipating change and undertaking actions to avoid the negative consequences and take advantage of the potential benefits of those changes. Forest managers are accustomed to considering the long-term implications of their decisions. However, many are now responding to much shorter-term economic or political imperatives. Climate change potentially increases the consequences of many existing challenges associated with environmental, social, or economic change. Some current management measures may continue to be suitable in responding to increasing pressures under climate change, while for other situations new measures will be required. This special issue presents papers from Africa, Europe, and North America that provide examples of the type of analysis being implemented to support forest management in a changing climate. The implications in the context of uncertainty in climate projections and ecosystem responses are discussed.