Forests provide a range of ecosystem services essential for human wellbeing. In a changing climate, forest management is expected to play a fundamental role by preserving the functioning of forest ecosystems and enhancing the adaptive processes. Understanding and quantifying the future forest coverage in view of climate changes is therefore crucial in order to develop appropriate forest management strategies. However, the potential impacts of climate change on forest ecosystems remain largely unknown due to the uncertainties lying behind the future prediction of models. To fill this knowledge gap, here we aim to provide an uncertainty assessment of the potential impact of climate change on the forest coverage in Italy using species distribution modelling technique. The spatial distribution of 19 forest tree species in the country was extracted from the last national forest inventory and modelled using nine Species Distribution Models algorithms, six different Global Circulation Models (GCMs), and one Regional Climate Models (RCMs) for 2050s under an intermediate forcing scenario (RCP 4.5). The single species predictions were then compared and used to build a future forest cover map for the country. Overall, no sensible variation in the spatial distribution of the total forested area was predicted with compensatory effects in forest coverage of different tree species, whose magnitude and patters appear largely modulated by the driving climate models. The analyses reported an unchanged amount of total land suitability to forest growth in mountain areas while smaller values were predicted for valleys and floodplains than high-elevation areas. Pure woods were predicted as the most influenced when compared with mixed stands which are characterized by a greater species richness and, therefore, a supposed higher level of biodiversity and resilience to climate change threatens. Pure softwood stands along the Apennines chain in central Italy (e.g., Pinus, Abies) were more sensitive than hardwoods (e.g., Fagus, Quercus) and generally characterized by pure and even-aged planted forests, much further away from their natural structure where admixture with other tree species is more likely. In this context a sustainable forest management strategy may reduce the potential impact of climate change on forest ecosystems. Silvicultural practices should be aimed at increasing the species richness and favoring hardwoods currently growing as dominating species under conifers canopy, stimulating the natural regeneration, gene flow, and supporting (spatial) migration processes.