Emerging after World War II ‘‘the environment’’ as a modern concept turned in the years around 1970 into a phase of institutionalization in science, civic society, and politics. Part of this was the foundation of journals. The majority became ‘‘environmental specialist journals’’, typically based in established disciplines. Some became ‘‘environmental generalist journals’’, covering broad knowledge areas and often with an ambition to be policy-relevant. A significant and early member of the latter category was Ambio, founded in 1972. This article presents an overview of the journal’s first 50 years, with a focus on main changes in scientific content, political context, and editorial directions. A key finding is that the journal reflects an increasing pluralization of ‘‘the environment’’ with concepts such as global change, climate change, Earth system science, Anthropocene, resilience, and environmental governance. Another finding is that the journal has also itself influenced developments through publishing work on new concepts and ideas.