The Mediterranean Region currently faces major environmental issues that require constant analysis and monitoring. This study presents a thorough approach based on the application of Landsat imagery from Global Forest Change during 2001–2019. Spatial distribution mapping was one of the objectives of the study. We approached the analysis of tree cover loss areas by analyzing the cumulative tree cover loss and Tree Cover Loss Rate. This indicator offers information about the trend of tree cover loss in each Mediterranean country. A total of 581 Mha of the deforested area was mapped during the analyzed period. Analysis was further supplemented by some statistical operations (distributions shown via histograms, validation via Shapiro–Wilk normality test, and testing via one-sample t-test). Agricultural expansion, intense forest fires, illegal logging, overgrazing (especially in the northern part of Africa), and extensive livestock farming have influenced the Mediterranean forest ecosystem stability. The continuation of these activities could cause extreme climatic events, severe degradation, and desertification.
